Endocrine Abstracts

Introduction: Diabetes mellitus is associated with an increased risk of osteoporotic fractures, which leads to an increased risk of disability and frailty.Aims: To assess the prevalence of frailty in type 2 diabetes and to analyze the relationship with bone mineral density (BMD) and Trabecular Bone Score (TBS), fracture risk and prevalent fractures.Methods: We carried out a cross-sectional study of 75 diabetic patients (65±7 y...

Objective: Endogenous cushing syndrome (ECS) is a complex and rare disease. After treatment, 50% of cases have recurrence. The objective is to evaluate the prevalence of recurrences in patients diagnosed of ECS and its predictive factors.Materials and Methods: Analytical retrospective observational study with 19 ECS diagnoses cases followed-up from January 1999 to December 2023. Demographic (sex, age), clinical (cause, face plethora, fragile capillary, r...

Aim: To evaluate the efficacy of second-line therapies in patients with acromegaly caused by a GH and PRL cosecreting pituitary neuroendocrine tumor (GH&PRL-Pit-NET) and those caused by a GH-Pit-NET.Methods: A multicenter retrospective clinical practice study of 679 patients with acromegaly in follow-up in 33 tertiary hospitals (ACRO-SPAIN study). For this analysis, only patients on treatment with pasireotide or pegvisomant in monotherapy or in combi...